I-GMP-TL778 Anti-Human CD137 mAb Idala ukwanda kwamaseli e-T kanye nokukhiqizwa kwe-cytokine

I-4-1BB, eyaziwa nangokuthi i-CD137, i-inducible cell surface receptor kanye nelungu elilodwa le-tumor necrosis factor receptor (i-tumor necrosis factor receptor, TNFR) superfamily. I-CD137 ifakwe ikhodi yofuzo lwe-tumor necrosis factor receptor ilungu lomndeni omkhulu ongu-9 (TNFRSF9) futhi ivezwe kabanzi endaweni yamaseli T acushiwe namaseli e-NK. I-ligand yayo, i-CD137L, nayo eyilungu le-TNFSF, iyisamukeli se-costimulatory engakholeki esivezwa amaseli e-CD4 + ne-CD8 + T acushiwe, i-NKT, NK cell, DC, macrophages, eosinophils, neutrophils nama-mast cell, ikakhulukazi kumaseli e-CD8 + T. I-CD137 / CD137L ilamula izimpendulo zamasosha omzimba ngokudlulisa amasiginali wokuvula, ukwanda, noma ama-apoptotic phakathi kwamaseli omzimba. Ukwenziwa kusebenze kwe-CD137 kungashukumisa i-NK cell kanye ne-T cell ukwanda futhi kukhiqize umsebenzi wokulwa nesimila, oheha izimpendulo zenkumbulo ezihlala isikhathi eside. I-4-1BB mAb ingenza kusebenze i-4-1BB ukuze ibuthe izici ezihlobene ne-TNFR i-TRAF1 ne-TRAF2. Bese, i-TRAF1 ne-TRAF2 benza i-heterotrimer, eqinisa ukudluliswa kwesignali nge-c-Jun N terminal kinase (JNK) noma indlela ye-extracellular signal-regulated kinase (ERK). Le heterotrimer ingakhuthaza ukwanda kwamangqamuzana e-T namangqamuzana e-antigen-presenting, ithuthukise ukusabela kwe-immune ye-anti-tumor yomzimba futhi ikhiphe ama-cytokines ngokubhaliswa kwe-NF-κB.