I-GMP-TL502 Anti-Human CD52 mAb T cell activation kanye nokwanda

I-CD52 iyi-antigen esabalaliswe kabanzi eyingxenye ye-GPI anchored glycoprotein enezinsalela ze-amino acid eziyishumi nambili kuphela (GQNDTSQTSSPS). I-CD52 ingatholakala ebusweni be-lymphocyte, ama-monocyte, ama-eosophil namaseli e-dendritic ohlelweni lwe-hematopoietic. ngokuminyana okungafika ku-5×10⁵molecules kuma-lymphocyte, ama-CD52 antigen aveza izifo eziningi zamaseli e-lymphoid kanye namaseli athile e-acute myeloid leukemia. Uma ama-molecule e-CD52 exhunyaniswe ne-mAb, iqala uchungechunge lokusayina ngaphakathi kwamaseli okuqondiwe. Ukusayinda okubangelwa ukwenziwa kusebenze kwama-CD52 molecule kuyefana nalokho okubangelwa amasosha omzimba alwa ne-CD3. Uma ama-molecule e-CD52 eqalwa, i-PMA (i-Phorbol Myristate acetate, i-acetylmyridrobol ester) ingakhuthaza ukwanda nokukhiqizwa kwama-cytokines ku-CD4⁺ kanye nama-CD8⁺Tlymphocyte e-vitro evamile.