I-GMP-TL778 Anti-Human CD137 mAb yenza ukwanda kweeseli ze-T kunye nokuphuma kwe-cytokine

I-4-1BB, eyaziwa ngokuba yi-CD137, i-inducible cell surface receptor kunye nelungu elinye le-tumor necrosis factor receptor (i-tumor necrosis factor receptor, i-TNFR) i-superfamily. I-CD137 ifakwe kwiikhowudi kwi-tumor necrosis factor receptor ilungu le-9 (TNFRSF9) gene kwaye ibonakaliswe ngokubanzi kumphezulu weeseli ze-T ezisebenzayo kunye neeseli ze-NK. I-ligand yayo, i-CD137L, nayo ilungu le-TNFSF, i-inducible costimulatory receptor echazwe yi-CD4 + kunye ne-CD8 + T esebenzayo, i-NKT, iiseli ze-NK, i-DC, i-macrophages, i-eosinophils, i-neutrophils kunye neeseli ze-mast, ngakumbi kwiiseli ze-CD8 + T. I-CD137 / CD137L ilamla iimpendulo ze-immune ngokudlulisela ukusebenza, ukwanda, okanye imiqondiso ye-apoptotic phakathi kweeseli zomzimba. Ukusetyenziswa kwe-CD137 kunokuvuselela i-NK cell kunye ne-T cell proliferation kunye nokuvelisa umsebenzi wokuchasana ne-tumor, obangela iimpendulo zememori ezihlala zihleli. I-4-1BB mAb inokuvula i-4-1BB ukuze ifune izinto ezinxulumene ne-TNFR i-TRAF1 kunye ne-TRAF2. Emva koko, i-TRAF1 kunye ne-TRAF2 zenza i-heterotrimer, eyomeleza ukuhanjiswa kwesignali nge-c-Jun N terminal kinase (JNK) okanye i-extracellular signal-regulated kinase (ERK) indlela. Le heterotrimer inokukhuthaza ukwanda kweeseli ze-T kunye neeseli ze-antigen-presenting, ukuphucula impendulo ye-anti-tumor ye-immune yomzimba kunye ne-secrete cytokines ngokubhalwa kwe-NF-κB.