GMP-TL778 Ka-hortagga Aadanaha CD137 mAb Waxay keentaa kororka unugyada T iyo dheecaanka cytokine

4-1BB, oo sidoo kale loo yaqaan CD137, waa soo-dhoweeye unug oogada sare ah oo aan la dafiri karin iyo hal xubin oo ka mid ah soo-dhoweeyaha necrosis factor (qaadaha necrosis factor receptor, TNFR) superfamily. CD137 waxaa lagu calaamadeeyay unugyada necrosis factor receptor superfamily 9 (TNFRSF9) hiddo-wadaha oo si ballaaran loogu muujiyey dusha unugyada T ee firfircoonida iyo unugyada NK. Xarunteeda, CD137L, sidoo kale xubin TNFSF ah, waa soo-dhoweeye costimulatory ah oo la taaban karo oo lagu muujiyay unugyada CD4 + iyo CD8 + T, NKT, unugyada NK, DC, macrophages, eosinophils, neutrophils iyo unugyada mast, gaar ahaan unugyada CD8 + T. CD137 / CD137L waxay dhexdhexaadisaa jawaabaha difaaca iyagoo gudbiya firfircooni, fidin, ama calaamadaha apoptotic ee u dhexeeya unugyada difaaca. Dhaqdhaqaaqa CD137 waxay kicin kartaa unugyada NK iyo kororka unugyada T waxayna dhalin karaan firfircoonida ka hortagga burooyinka, taas oo keenta jawaabaha xusuusta waara. 4-1BB mAb waxay dhaqaajin kartaa 4-1BB si ay u qorto arrimaha la xidhiidha TNFR TRAF1 iyo TRAF2. Kadib, TRAF1 iyo TRAF2 waxay sameeyaan heterotrimer, taas oo xoojisa gudbinta calaamadaha iyada oo loo marayo c-Jun N terminal kinase (JNK) ama dariiqa kinase-ka-xukunka ah ee ka baxsan unugga (ERK). Heterotrimer-kani wuxuu kicin karaa kororka unugyada T-yada iyo unugyada antigen-soo-bandhiga, hagaajinta jawaab-celinta difaaca-ka-hortagga buro ee jirka iyo qarsoodiga cytokines iyada oo loo marayo qoraalka NF-kB.