GMP-TL778 Anti-Human CD137 mAb Inoita kuti T masero awedzere uye kugadzirwa kwe cytokine.

4-1BB, inozivikanwawo seCD137, inducible cell surface receptor uye imwe nhengo ye tumor necrosis factor receptor (tumor necrosis factor receptor, TNFR) superfamily. CD137 inovharidzirwa ne tumor necrosis factor receptor superfamily member 9 (TNFRSF9) gene uye inoratidzirwa zvakanyanya pamusoro pemaT cells akaiswa uye NK masero. Its ligand, CD137L, uyewo nhengo yeTNFSF, inonzi inducible costimulatory receptor inoratidzwa neCD4 + uye CD8 + T masero, NKT, NK masero, DC, macrophages, eosinophils, neutrophils uye mast masero, kunyanya paCD8 + T masero. CD137 / CD137L inopindirana nemhinduro dzekudzivirira nekutapurirana activation, kupararira, kana maapoptotic masaini pakati pemasero ekudzivirira. Iko kushandiswa kweCD137 kunogona kukurudzira NK cell uye T masero kuwanda uye kuunza anti-bundu chiitiko, izvo zvinoita kuti ndangariro dzirambe dzichipindura. 4-1BB mAb inogona kushandura 4-1BB kuti itore TNFR inoenderana zvinhu TRAF1 uye TRAF2. Zvadaro, TRAF1 uye TRAF2 inoumba heterotrimer, iyo inosimbisa kutenderera kwechiratidzo kuburikidza ne c-Jun N terminal kinase (JNK) kana extracellular signal-regulated kinase (ERK) nzira. Iyi heterotrimer inogona kukurudzira kupararira kwemasero eT uye masero e-antigen-presenting, kuvandudza anti-tumor immune response yemuviri uye secrete cytokines kuburikidza nekunyorwa kweNF-κB.