Champion Yokonza M'malo Otentha Kwambiri! T&L Biotechnology Ikhazikitsa Mwalamulo Mapuloteni a New Generation Thermostable bFGF
Basic Fibroblast Growth Factor (bFGF), membala wa fibroblast growth factor family, imayambitsa ma signature transduction pathways pomanga ndi kuyambitsa ma receptor omwe akufuna.T cell pamwamba. bFGF imayang'anira kuchuluka kwa mitundu yosiyanasiyana ya maselo, kuphatikiza ma endothelial cell, neurons, chondrocytes, maselo osalala a minofu, ma melanocytes, ndi adipocytes. Kuphatikiza apo, bFGF imakhudzidwa ndi zochitika zachilengedwe monga kudzikonzanso kwa ma cell, kusiyanitsa, chitukuko, kukonza minofu, ndi kusinthika. Monga chinthu chofunikira kwambiri pakukula kwa maselo, bFGF imagwiritsidwa ntchito kwambiri mu chikhalidwe cha in vitro chamitundu yosiyanasiyana yama cell.
Kafukufuku akuwonetsa kuti bFGF ndi yosakhazikika pansi pa zochitika za thupi, ndi theka la moyo wa maola pafupifupi 8 mu zikhalidwe zama cell a mammalian. Kukhazikika kwamafuta ochepa komanso theka la moyo waufupi wa bFGF kumabweretsa zovuta zama cell, zomwe zimafunikira pafupipafupi kukula kwa chinthu kapena kusintha sing'anga tsiku lililonse. Puloteni ya bFGF yotentha, yopangidwa ndi kusintha kwa bFGF yachilengedwe, imathetsa vutoli. Imasungabe mphamvu yachilengedwe ya bFGF pomwe imathandizira kukhazikika kwamafuta, kusunga kukhulupirika kwadongosolo komanso ntchito zama protein pa kutentha kwakukulu.
Munthu embryonic Stem Cells (hESCs) ndi maselo opangidwa ndi pluripotent stem cell (iPSCs) ali ndi kuthekera kosiyana mumitundu yonse yama cell. Panthawi ya chikhalidwe cha in vitro cha hESCs ndi iPSCs, bFGF ndiyofunikira kuti musunge ma stem cell pluripotency. Kafukufuku amasonyeza kuti hESCs otukuka ndi thermostable bFGF kupanga madera osagwirizana mofulumira (mkuyu. 1A) ndi kusonyeza kumatheka kuchulukana mitengo pa nthawi yaitali chikhalidwe (mkuyu. 1B). Kafukufuku winanso akuwonetsa kuti thermostable bFGF imalimbikitsa kuchulukira kwa hESC kwinaku akusunga mawu a zolembera za kuchuluka (mwachitsanzo, OCT4, SOX2, KLF4), kutsimikizira kuthekera kwake kosunga kuchuluka kwa heSC-chinthu chofunikira kwambiri pakugwiritsa ntchito chikhalidwe cha ma cell.
A: Kukula kwa ma hESC pa Tsiku 2 pansi pa chikhalidwe chopanda chakudya chokhala ndi mitundu yosiyanasiyana ya bFGF.
B: Kuyerekeza kwa kukula kwa maselo pachikhalidwe chopitilira ndi WT-bFGF (mtundu wakutchire) kapena TS-bFGF (thermostable) pansi pamikhalidwe yopanda chakudya.
Product Launch
Recombinant Human bFGF Protein (Heat Stable)
Zogulitsa Zamalonda
- Thermostable
- Kuyera Kwambiri (> 90%)
- Ntchito Yapamwamba
- Endotoxin Yochepa (
- Wosabala
- Mycoplasma-Free
Magwiridwe Azinthu
pplication Scenario
Mukawonjezeredwa ku sing'anga ya chikhalidwe cha iPSC, kusintha kwapakatikati kumatha kuchitika masiku awiri aliwonse.
Monga momwe tawonetsera mkuyu 5, T & L's Recombinant Human bFGF Protein (GMP-TL901) ndi Thermostable bFGF inagwiritsidwa ntchito ku AMMS® Pluripotent Stem Cell Medium (AS-35) kwa chikhalidwe cha iPSC. Pakatikati, kuphatikiza ndi thermostable bFGF, kusintha kwapakati pa tsiku kapena tsiku lililonse kumapangitsa kuti ziwerengero ndi makulidwe awo azikhala bwino poyerekeza ndi bFGF wamba. Makamaka, kutheka kwa ma cell sikunawonetse kusiyana kwakukulu pakati pa ma protocol atsiku ndi tsiku omwe ali ndi bFGF yotentha, kutsimikizira kukwanira kwake pachikhalidwe cha iPSC chotsika mtengo.
Kodi mukufuna kuyesa Protein yathu ya New Generation Thermostable bFGF?
Lumikizanani nafe lero kuti mupemphe zitsanzo zaulere ndikupeza mapindu a kafukufuku wanu!
T&L Biotechnology Co., Ltd. imayang'ana kwambiri kafukufuku ndi chitukuko cha zinthu zakumtunda, zamtundu wa GMP ndi zopangira ma cell ndi ma reagents. Gene Therapy (CGT). Ndife odzipereka kupereka mayankho okwana kwa makasitomala a CGT kudzera pazogulitsa zathu zonse ndi mautumiki. Zogulitsa zathu zikuphatikizapo kupatukana kwa cell ndi activation maginito mikanda, Eukaryotic/prokaryotic recombinant protein, sing'anga yopanda seramu, zida zama cell, ndi zina.
Timagwiritsa ntchito labotale yofufuza ndi chitukuko komanso msonkhano waukhondo wa 3,200-square-metres GMP-level. Malowa akuphatikizanso nsanja zolekanitsa ma cell maginito chitukuko, eukaryotic ndi prokaryotic protein expression engineering, ndi chitukuko chapakati chopanda seramu. Timatsatira miyezo ya ISO 13485 ndi ISO 9001 Quality Management System. Kuphatikiza apo, zina mwazinthu zathu zili ndi zolemba za FDA DMF.