GMP-TL778 Anti-Human CD137 mAb Imapangitsa kuti T cell ichuluke komanso kutulutsa kwa cytokine

4-1BB, yomwe imadziwikanso kuti CD137, ndi cholandilira cell surface receptor komanso membala m'modzi wa tumor necrosis factor receptor (tumor necrosis factor receptor, TNFR) superfamily. CD137 ndi encoded ndi chotupa necrosis factor receptor superfamily membala 9 (TNFRSF9) jini ndi mofala padziko adamulowetsa T maselo ndi NK maselo. Ligand yake, CD137L, yemwenso ndi membala wa TNFSF, ndi inducible costimulatory receptor yomwe imawonetsedwa ndi ma CD4 + ndi CD8 + T maselo, NKT, NK maselo, DC, macrophages, eosinophils, neutrophils ndi mast cell, makamaka pa CD8 + T maselo. CD137 / CD137L imayanjanitsa mayankho a chitetezo chamthupi potumiza ma activation, kufalikira, kapena ma sign a apoptotic pakati pa ma cell a chitetezo. Kutsegula kwa CD137 kumatha kulimbikitsa NK cell ndi T cell kuchulukira ndikupanga anti-chotupa ntchito, zomwe zimathandizira kukumbukira kukumbukira. 4-1BB mAb ikhoza kuyambitsa 4-1BB kuti ipeze zinthu zokhudzana ndi TNFR TRAF1 ndi TRAF2. Kenako, TRAF1 ndi TRAF2 zimapanga heterotrimer, yomwe imalimbitsa ma transduction kudzera mu c-Jun N terminal kinase (JNK) kapena extracellular signal-regulated kinase (ERK) njira. Heterotrimer iyi ikhoza kulimbikitsa kuchuluka kwa maselo a T ndi ma antigen-presenting cells, kupititsa patsogolo chitetezo cha mthupi chotsutsana ndi chotupa cha thupi ndi kutulutsa ma cytokines kupyolera mu kulembedwa kwa NF-κB.