Qhov Kho tau yeej nyob rau hauv qhov kub-kub ib puag ncig! T&L Biotechnology Tshaj Tawm Tshiab-Tshiab Thermostable bFGF Protein
Basic Fibroblast Growth Factor (bFGF), ib tug tswv cuab ntawm tsev neeg fibroblast kev loj hlob, ua rau cov kev taw qhia kev hloov pauv los ntawm kev khi rau thiab ua kom cov receptors ntawm targeT Cell nto. bFGF tswj kev loj hlob ntawm ntau hom cell, suav nrog cov hlwb endothelial, neurons, chondrocytes, cov leeg nqaij du, melanocytes, thiab adipocytes. Tsis tas li ntawd, bFGF koom nrog hauv cov txheej txheem lom neeg xws li kev rov ua dua tshiab ntawm tes, kev sib txawv, kev loj hlob, kho cov ntaub so ntswg, thiab rov tsim dua tshiab. Raws li ib qho tseem ceeb rau kev loj hlob ntawm tes, bFGF yog dav siv nyob rau hauv vitro kab lis kev cai ntawm ntau hom cell.
Cov kev tshawb fawb qhia tias bFGF tsis ruaj khov nyob rau hauv lub cev nqaij daim tawv, nrog ib nrab-lub neej ntawm kwv yees li 8 teev nyob rau hauv cov kab lis kev cai mammalian cell. Qhov qis thermal stability thiab luv luv ib nrab-lub neej ntawm bFGF ua rau muaj kev sib tw hauv kab lis kev cai ntawm tes, xav tau kev loj hlob ntxiv los yog hloov nruab nrab txhua hnub. Lub thermostable bFGF protein, tsim los ntawm kev hloov kho ntawm ntuj bFGF, hais txog qhov kev sib tw no. Nws khaws cov khoom siv roj ntsha muaj zog ntawm ntuj bFGF thaum ua tiav kev txhim kho thermal stability, tswj cov txheej txheem kev ncaj ncees thiab cov protein ua haujlwm thoob plaws qhov kub thiab txias.
Tib neeg embryonic Stem Cells (hESCs) thiab induced pluripotent qia hlwb (iPSCs) muaj peev xwm sib txawv rau txhua hom somatic cell. Thaum nyob hauv vitro kab lis kev cai ntawm hESCs thiab iPSCs, bFGF yog qhov tseem ceeb rau kev tswj cov qia cell pluripotency. Kev tshawb fawb pom tau hais tias hESCs kab lis kev cai nrog cov thermostable bFGF daim ntawv tsis sib txawv ntawm cov cheeb tsam sai dua (Fig. 1A) thiab nthuav tawm cov kev loj hlob ntawm cov kab lis kev cai mus sij hawm ntev (Fig. 1B). Cov kev tshawb fawb ntxiv qhia tau hais tias cov thermostable bFGF txhawb nqa hESC kev loj hlob thaum txhawb nqa kev qhia ntawm pluripotency cov cim (xws li OCT4, SOX2, KLF4), ua pov thawj nws lub peev xwm los khaws hESC pluripotency-ib qho tseem ceeb rau kev siv kab lis kev cai ntawm tes.
A: Kev loj hlob ntawm hESCs nyob rau Hnub 2 nyob rau hauv cov kab lis kev cai pub pub dawb nrog cov bFGF sib txawv.
B: Kev sib piv ntawm cell loj hlob tus nqi thaum lub sij hawm tas mus li kab lis kev cai nrog WT-bFGF (wild-type) los yog TS-bFGF (thermostable) nyob rau hauv feeder-free tej yam kev mob.
Khoom Launch
Recombinant Tib Neeg bFGF Protein (Tshav Kub Kub)
Khoom nta
- Thermostable
- High Purity (> 90%)
- Kev Ua Haujlwm Siab
- Tsawg Endotoxin (
- Tsis muaj menyuam
- Mycoplasma-dawb
Product Performance
daim ntawv thov Scenario
Thaum ntxiv rau iPSC kab lis kev cai nruab nrab, kev hloov nruab nrab tuaj yeem ua txhua 2 hnub.
Raws li pom hauv daim duab 5, T&L's Recombinant Human bFGF Protein (GMP-TL901) thiab Thermostable bFGF tau siv rau AMMS® Pluripotent Stem Cell Medium (AS-35) rau iPSC kab lis kev cai. Hauv nruab nrab ntxiv nrog cov thermostable bFGF, txhua hnub lossis txhua hnub nruab nrab hloov pauv tau txhim kho cov lej thiab qhov ntau thiab tsawg piv rau bFGF li niaj zaus. Qhov tseem ceeb, kev muaj peev xwm ntawm tes tau pom tsis muaj qhov sib txawv tseem ceeb ntawm cov txheej txheem niaj hnub thiab txhua hnub nrog cov thermostable bFGF, ua kom pom tseeb tias nws tsim nyog rau tus nqi siv iPSC kab lis kev cai.
Txaus siab rau sim peb Cov Txheej Txheem Tshiab Thermostable bFGF Protein?
Hu rau peb hnub no kom thov tus qauv dawb thiab paub txog cov txiaj ntsig ua ntej rau koj qhov kev tshawb fawb!
T&L Biotechnology Co., Ltd. tsom rau kev tshawb fawb thiab kev loj hlob ntawm cov dej ntws, GMP-qib raw khoom thiab reagents rau cell thiab Gene Therapy (CGT). Peb tau cog lus los muab tag nrho cov kev daws teeb meem rau CGT cov neeg siv khoom los ntawm peb cov khoom lag luam thiab kev pabcuam. Peb cov khoom suav nrog kev sib cais ntawm tes thiab activation magnetic hlaws, eukaryotic / prokaryotic recombinant proteins, tsis muaj ntshav nruab nrab, cov khoom siv ntawm tes, thiab ntau dua.
Peb ua lub chaw soj ntsuam thiab kev tsim kho thiab 3,200-square-meter GMP-theem huv rhiav. Cov chaw no muaj xws li platforms rau kev sib cais ntawm tes sib nqus hlaws txoj kev loj hlob, eukaryotic thiab prokaryotic protein qhia engineering, thiab kev loj hlob tsis muaj ntshav qab zib. Peb ua raws li ISO 13485 thiab ISO 9001 Kev Tswj Xyuas Txheej Txheem Zoo. Tsis tas li ntawd, qee qhov ntawm peb cov khoom muaj FDA DMF cov ntaub ntawv.