GMP-TL778 Anti-Human CD137 mAb Yana haifar da haɓakar ƙwayoyin T da ɓarnawar cytokine

4-1BB, wanda kuma aka sani da CD137, shine mai karɓar sararin samaniya mai inducible kuma memba ɗaya na ƙwayar cuta necrosis factor receptor (tumor necrosis factor receptor, TNFR) superfamily. CD137 an ɓoye shi ta hanyar ƙwayar cuta necrosis factor receptor superfamily memba 9 (TNFRSF9) gene kuma an bayyana ko'ina akan saman ƙwayoyin T da aka kunna da ƙwayoyin NK. Ƙungiyarsa, CD137L, kuma memba na TNFSF, mai karɓa ne mai ƙima mai mahimmanci wanda aka bayyana ta CD4 + da CD8 + T Kwayoyin, NKT, NK Kwayoyin, DC, macrophages, eosinophils, neutrophils da mast Kwayoyin, musamman a kan CD8 + T Kwayoyin. CD137 / CD137L yana daidaita martanin rigakafi ta hanyar watsa kunnawa, haɓakawa, ko siginar apoptotic tsakanin ƙwayoyin rigakafi. Kunna CD137 na iya tayar da ƙwayoyin NK da yaduwar kwayar cutar T da kuma haifar da aikin anti-tumor, wanda ke haifar da amsawar ƙwaƙwalwar ajiya mai dorewa. 4-1BB mAb na iya kunna 4-1BB don ɗaukar abubuwan da suka danganci TNFR TRAF1 da TRAF2. Sa'an nan, TRAF1 da TRAF2 suna samar da heterotrimer, wanda ke ƙarfafa siginar siginar ta hanyar c-Jun N m kinase (JNK) ko kuma hanyar kinase (ERK). Wannan heterotrimer na iya haɓaka haɓakar ƙwayoyin T da ƙwayoyin da ke gabatar da antigen, inganta haɓakar rigakafin ƙwayar cuta na jiki da ɓoye cytokines ta hanyar rubutun NF-kB.