0102030405
GMP-TL112 Anti-Human CD20 mAb Targeted induction of B cell apoptosis
CD20 is a specific signature molecule on the surface of B lymphocytes and is expressed on more than 95% of normal or malignant B lymphocytes. There is no expression of CD20 antigen in hematopoietic stem cells, progenitor cells, and other normal tissues. It consists of 297 amino acids with a molecular weight of 33 kD. CD20 has no internalization or cell surface shedding after binding with anti-CD20 mAb , which is an ideal antigen in the treatdment of B lymphocyte-related diseases. Anti-CD20 mAb can kill most of the lymphoma cells expressing CD20 molecules and normal B cells. Innate normal B cells are not affected by anti-CD20 mAb and can reconstruct B cell population. Therefore, anti-CD20 monoclonal antibodies are increasingly used in the treatment of B cell-related diseases
| Cytokines | |
| QC Testing Purity | > 90 % as determined by SDS-PAGE. |
| Endotoxin | < 0.1EU per μg of the protein as determined by the LAL method. |
| Formulation | Supplied as a 0.22μm filtered solution in PBS, PH 7.4 |
| Monoclonal Antibodies | |
| Biological activity | The binding rate with PBMCs |
| Expression Host | CHO cells |
| Purification： | Protein A purified from cell culture supernatant. |
| Stability & Storage | 24 months at 2℃ to 8℃. Avoid repeated freeze-thaw cycles. |
| Thumb | File information |
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GMP-TL502_SDS.pdf |
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GMP-TL502_Product Sheet.pdf |