0102030405
GMP-TL101 Anti-Human CD3 mAb Antigen recognition, signal transduction and T cell activation
Product Overview
Anti-Human CD3 mAb (GMP TL101) is engineered to facilitate antigen recognition, signal transduction, and T cell activation. This monoclonal antibody is a vital component for both research and clinical applications involving T cell manipulation.
Key Features
● Signal Transduction: Effectively mediates antigen recognition and signal transduction, crucial for T cell activation.
● GMP Manufacturing: Produced under stringent GMP conditions to ensure product quality and reproducibility.
● High Specificity: High specificity for CD3, ensuring precise targeting and minimal off-target effects.
● Broad Applicability: Suitable for various applications, including flow cytometry, cell culture, and therapeutic research.
Applications
● Immunological Research: Essential for studying T cell receptor (TCR) signaling and activation pathways.
● Therapeutic Development: Aids in the development of T cell-based therapies, including CAR-T therapy.
● Clinical Studies: Suitable for clinical research protocols requiring high-quality, GMP-compliant antibodies.
Specifications and Packaging
● Specifications:
Available in multiple sizes to suit diverse experimental needs: 100μg, 500μg, and 1mg.
High-quality standards ensure consistency and reliability.
● Packaging:
Supplied as sterile liquid or lyophilized powder for ease of use and convenient storage.
Packaged to maintain integrity and effectiveness during transport and handling.
Storage and Stability
Storage
For short-term use, store at 2-8°C.
For long-term storage, keep at -20°C to preserve antibody stability and activity.
Avoid repeated freeze-thaw cycles to prevent degradation.
Stability
Maintains stability under recommended storage conditions, ensuring reliable performance in research applications.
Designed for durability, guaranteeing long-term effectiveness.
Instructions for Use
Dilute the antibody in an appropriate buffer or medium prior to use.
Prepare and use the solution as per experimental requirements for accurate and reproducible results.
Follow the relevant protocols for your application, whether it’s flow cytometry, immunohistochemistry, or functional assays.
Cautions
• This product is intended solely for research use and is not suitable for clinical diagnostics or therapeutic applications.
• Handle the antibody according to the provided instructions to maintain its activity and integrity.
• For any issues or inquiries, please contact our technical support team for assistance.
• Optimize your research with our versatile and reliable antibodies. For detailed product information and support, visit our website.
| Monoclonal Antibodies | |
| Applications | Soluble method: the concentration of 500 ng/mL is recommended, under which T cells can be activated and CD3⁺CD56⁺T cells can be expanded significantly. |
| Biological activity | The binding rate with Jurkat cells shall not be less than 90% |
| Coating method: | 10 mL PBS buffer (5μg/mL anti-human CD3) is placed in a T75 flask at 4°C overnight. Please remove the PBS and wash the flask with saline gently three times before use. |
| Endotoxin | < 0.01EU per μg of the protein as determined by the LAL method. |
| Expression Host | CHO cells |
| Formulation | Supplied as a 0.22μm filtered solution in PBS, PH 7.4 |
| Purification： | Protein A purified from cell culture supernatant |
| QC Testing Purity | > 95 % as determined by SDS-PAGE |
| Stability & Storage | 24 months at 2℃ to 8℃. Avoid repeated freeze-thaw cycles |
| Thumb | File information |
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GMP-TL101_SDS.pdf |
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GMP-TL101_Product Sheet.pdf |